{"id":2828,"date":"2025-06-20T15:36:42","date_gmt":"2025-06-20T15:36:42","guid":{"rendered":"https:\/\/dta.cnr.it\/2025\/06\/20\/base-editing-unlocking-safer-precise-and-complex-genome-engineering-for-therapeutics-and-discovery\/"},"modified":"2025-06-20T15:36:42","modified_gmt":"2025-06-20T15:36:42","slug":"base-editing-unlocking-safer-precise-and-complex-genome-engineering-for-therapeutics-and-discovery","status":"publish","type":"post","link":"https:\/\/dta.cnr.it\/en\/2025\/06\/20\/base-editing-unlocking-safer-precise-and-complex-genome-engineering-for-therapeutics-and-discovery\/","title":{"rendered":"Base Editing: unlocking safer, precise, and complex genome engineering for therapeutics and discovery"},"content":{"rendered":"<p><em>Il 26\/06\/2025 ore 14.30 &#8211; 16.00<\/em>.<\/p>\n<p>CRISPR-based technologies have transformed genome engineering, yet their reliance on double-strand DNA breaks (DSBs) poses challenges, particularly for applications requiring precision, safety, and multiplexing. Base editors have emerged as next-generation tools, enabling efficient and precise single nucleotide changes without introducing DSBs. In this seminar, I will introduce the principles of CRISPR-based genome engineering with a particular focus on base editing and its expanding role in therapeutic and research applications.<br \/>\nI will highlight Revvity\u2019s Pin-point\u2122 platform, a &#8230;<\/p>\n<p><a href=\"https:\/\/www.cnr.it\/it\/evento\/19945\/base-editing-unlocking-safer-precise-and-complex-genome-engineering-for-therapeutics-and-discovery\" target=\"_blank\" class=\"feedzy-rss-link-icon\">Read More<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Il 26\/06\/2025 ore 14.30 &#8211; 16.00. CRISPR-based technologies have transformed genome engineering, yet their reliance on double-strand DNA breaks (DSBs) poses challenges, particularly for applications requiring precision, safety, and multiplexing. Base editors have emerged as next-generation tools, enabling efficient and precise single nucleotide changes without introducing DSBs. In this seminar, I will introduce the principles [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":2829,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[24],"tags":[],"class_list":["post-2828","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-eventi"],"_links":{"self":[{"href":"https:\/\/dta.cnr.it\/en\/wp-json\/wp\/v2\/posts\/2828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dta.cnr.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dta.cnr.it\/en\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/dta.cnr.it\/en\/wp-json\/wp\/v2\/comments?post=2828"}],"version-history":[{"count":0,"href":"https:\/\/dta.cnr.it\/en\/wp-json\/wp\/v2\/posts\/2828\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dta.cnr.it\/en\/wp-json\/wp\/v2\/media\/2829"}],"wp:attachment":[{"href":"https:\/\/dta.cnr.it\/en\/wp-json\/wp\/v2\/media?parent=2828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dta.cnr.it\/en\/wp-json\/wp\/v2\/categories?post=2828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dta.cnr.it\/en\/wp-json\/wp\/v2\/tags?post=2828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}