Replication of a complex viral DNA element by eukaryotic proteins

Jul 21, 2025 | Events

Il 24/07/2025 ore 14.30 – 16.00.

Il seminario sarà tenuto  tenuto dalla Dr.ssa Irene Gallina, Dipartimento di Medicina Molecolare – Università di Padova.
Herpesviruses are characterized by highly GC-rich genomes and several lines of evidence suggest the formation of G-quadruplexes (G4s) within these viral DNA sequences. Kaposis’s sarcoma associated herpesvirus (KSHV), the etiological agent of multiple lymphoproliferative diseases, contains an extensive non-coding repetitive region named terminal repeats (TRs) with a GC content higher than 80%. TRs are crucial for KSHV latency, mediating efficient …

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